What the endocannabinoid-system timeline means
After THC's structure was established, stereoselective effects supported the idea of specific biological targets. Researchers identified and cloned cannabinoid receptors, then isolated endogenous ligands including anandamide and 2-AG.
Cannabis findings depend on the product, dose, route of administration, population, and outcome measured. A result about one cannabinoid or formulation should not be generalized to every cannabis product.
How strong is the evidence?
We weigh systematic reviews and well-controlled human studies above observational reports, case series, animal studies, and laboratory experiments. Each can answer useful questions, but they do not support the same degree of certainty.
A receptor or pathway can explain mechanism without proving a treatment. Historical accounts should separate the date of an experimental result from later terminology, replication, and clinical interpretation.
What readers should do with this
Use this overview to frame better questions for a qualified clinician or researcher. It is not a diagnosis, treatment recommendation, dosing guide, or substitute for local legal advice.